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KMID : 0615720140310040081
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Jouranl of Korean Acupuncture and Moxibustion society
2014 Volume.31 No. 4 p.81 ~ p.97
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The Current Research Methodology of Pharmacopucture for the Treatment of Animal Cancer Models in Korea
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Ryu hee-Kyoung
Goo Bon-Hyuk
Suk Kyung-Hwan
Lee Ju-Hyeon
Ryu Soo-Hyeong
Lee Su-Yeon
Kim Min-Jeong
Park Yeon-Cheol
Baek Yong-Hyeon
Park Dong-Suk
Seo Byung-Kwan
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Abstract
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Objectives: The purpose of this study is analyzing the current research methodology of pharmacopucture for the treatment of animal cancer models.
Methods: Four electronic databases were searched for animal studies published from January 2000 to September 2014 onward using these search terms “cancer, anticancer, pharmaco-puncture, beevenom”. Selected articles were described about animal cancer models. The methods used to induce cancer and the outcome measures used to assess the effects of pharmacopuncture on animal cancer models were analyzed.
Results: 37 articles were included. For producing animal cancer models BALB/C mice(n=22) and C57BL/6 mice(n=17) were selected. And intravenous injection of B16-F10 melanoma cells into tail vein(n=14) or intraperitoneal injection of sarcoma-180 cells(n=14) were frequently used to induce cancer. Various pharmacopunctures were injected into acupoints CV12(n=19), ST36 (n=8), BL18(n=8) or peritoneal cavity(n=6), tumor site(n=2), tail vein(n=2). Outcome measures were categorized into anti-cancer, anti-metastasis, general condition, cytotoxicity, immune response, toxicity. Median Survival Time(MST) and increase of life span(ILS)(n=26) was frequently used for evaluating anti-cancer effects. And pulmonary colonization assay(n=13) was frequently used for evaluating anti-metastasis effects
Conclusions: Based on these data, further research would be needed to ascertain the effectiveness of pharmacopuncture for treating cancer and broaden the range of clinical applications.
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KEYWORD
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Cancer, Pharmacopuncture, Bee venom, Animal model.
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